The disease is a fulminant and high mortality rabbit intestinal disease caused by pathogenic E. coli. The disease is often caused by poor feed management, resulting in changes in the normal microbial flora of the intestine, and the spread of E. coli infestations caused by large numbers of inbreeders. [Pathogen] The pathogen is Escherichia coli, oval or rod-shaped, gram-negative, flagellate, and non-sporulating. They can produce toxins and cause disease. The bacteria resistance is not strong, general disinfection drugs can kill. The bacteria are widely found in nature and are common bacteria in the gut of humans and animals. Rabbits and a variety of animals are susceptible, mainly harming newborn rabbits and non- weaned pups of 1 month of age, the route of transmission is the digestive tract. [Symptoms and Lesions] The most acute cases can suddenly die without showing any symptoms. Newborn rabbits often have an acute process, diarrhea is not obvious or yellowish white watery feces, often with a large amount of gelatin-like mucus and a small amount of mouse feces-like dry stools; depressed spirit, rough hair dull, antifeedant, weight loss, weight loss Sometimes the abdomen swells; rabbits have cold limbs, molars, and runny nose; and die more than a week. After necropsy, the lesions were mainly in the digestive tract. Gastric dilatation, full of gas and fluid, mucus attached to the mucous membrane of the stomach; duodenum filled with gas and bile-contaminated fluid; jejunum dilated and filled with translucent gel-like liquid; often with two pointed, slender fecal balls in the ileum , The outer bread has mucus or white jelly-like secretions; the colon is dilated, there is a transparent glue-like mucus; the cecal contents are watery and there is a small amount of gas; the rectum is empty or full of viscose liquid; the serous and mucous membrane congestion of the colon and cecum Or bleeding (spots); gallbladder dilatation, mucosal edema. [Diagnosis] according to the rabbit abdominal swelling, severe diarrhea, row of yellow water faeces, containing viscous fluid and two sharp dry dung balls, acute onset, rapid infection, high mortality, can make a preliminary diagnosis. Bacteriological diagnosis can be made if necessary. [Control] disease-free rabbit farms, pups should be strengthened before and after weaning feeding management, regular quantitative feeding clean and digestible feed, changing feed should be a gradual transition, so that the intestinal bacteria have a process of adaptation. Rabbits should be immediately isolated, observed, and treated. Rabbit houses, rabbit cages and utensils are sterilized with lime water. The following prescriptions can be used for treatment: 1. Intramuscular injection of streptomycin, 10,000 to 20,000 units per kilogram of body weight, once daily for 2 consecutive days. Oral furazolidone, 21 mg/kg body weight, once daily, for 5 days. Norfloxacin 2g plus 3kg feed was mixed and fed for 2 days. 2. Oral convergence, stomachic drugs. Rhubarb soda tablets, young rabbits 2 grams, adult rabbits 35 grams, 26 grams of tannic acid protein, yeast tablets 22 grams, 1 day, and even served 3 days. 3. Intramuscular injection of amikacin, 20 mg per kilogram of body weight, or gentamycin, 20 ml per kilogram of body weight (containing 3 ml of 10,000 units), once daily. China Agricultural Network Editor