Pharmacological effects
Cassia is also known as "also the pupil", cassia seed contains a variety of vitamins and rich in amino acids, fats, carbohydrates, etc., its health care function has increasingly attracted people's attention. Cassia has Qingganhuo, rheumatism, Yishen Mingmu and other functions, often drink cassia seed tea, can make normal blood pressure, smooth stool, the old eyes do not spend. Clinical experiments show that drinking cassia seed tea can clear the liver and eyesight, prevent blurred vision, lower blood pressure, blood fat, cholesterol, etc., for prevention and treatment of coronary heart disease, hypertension have a good effect; and cassia seed rich in Vitamin A and zinc, can Prevent and treat night blindness and avoid zinc deficiency in children. In addition, Cassia Tea's function of laxative can also solve the problem of stomach and constipation in modern people. It can treat dry stools and help smooth bowel movements. The bubble method of cassia seed tea is very simple, as long as 15 to 20 grams of cassia seed with hot water can be brewed, but also according to personal preferences into the right amount of sugar, when the tea drinking, several times a day, if coupled with gardenia and chrysanthemum The effect is better. However, it is not recommended to drink this tea if the cassia seed is slightly cold and it is easy for people to feel diarrhea, diarrhea and stomachache.
1. Antibacterial activity: Cassia alcohol extracts have inhibitory effects on staphylococcus, diphtheria bacillus, typhoid bacillus, paratyphoid bacillus, and escherichia coli, while water extracts are ineffective.
2. Anti-fungus: Inoculum was diluted with test tubes, 1:20 inhibited Microsporum odontoides, and 1:10 inhibited both Streptosphaera fuliginea and Plasmodium microsporum.
3. Antihypertensive: Infusions and alcohol extracts have antihypertensive effect on anesthetized dogs, cats and rabbits.
4. Hypolipidemic effect: Cassia lucidum decoction or cassia seed powder 6g/feeding rats for 8 weeks, can reduce plasma cholesterol, triglyceride, and reduce liver triglyceride content in experimental hyperlipidemic rats.
5. Anti-platelet aggregation: Cassia seed decoction or powder 6g/kg fed rats for 8 weeks, inhibition of ADP-induced rat platelet aggregation.
6. Effect on immune function Cassia seed water decoction and alcohol decoction agent 15g/kg subcutaneous injection can make mice thymus atrophy, peripheral blood lymphocytes ANAE staining negative rate was significantly reduced, caused by 2,4-dinitrochlorobenzene (DNCB) Delayed hypersensitivity of the skin in mice was inhibited, but there was no significant effect on the formation of serum hemolysin. In addition, water and alcohol decoction of cassia seed can significantly increase the percentage of erythrocytes and phagocytic index of chicken peritoneal macrophages phagocytosing chicken lysozyme. Significantly higher than the control group.
7. Hepatoprotective effect of cassia seed hot water extract orally 670mg/kg on the liver of mice poisoned by carbon tetrachloride has a weak detoxification effect. Cassia was delipidated with petroleum ether, extracted with chloroform, and extracted with methanol. As a result, the methanol extract had a significant hepatoprotective effect. Further, it was found that the chrysophanol-lO-triglucosidase and chrysophanol-1-O-tetraglucosidase had a weak protective effect on carbon tetrachloride-injured hepatocytes at 1 mg/ml, and it was also found that aloe-emodin was also similar. The anti-hepatotoxic effect.
8. diarrhea effect Cassia has laxative effect. The leaching effect of oral extracts after oral administration peaked at 3-5h. A 50% ethanol-soluble fraction was obtained from the decoction, and ethyl acetate and butyric acid were sequentially used to obtain the soluble fraction and the water-soluble fraction, respectively. The butanol fraction with the highest purgative activity was separated on the Sephadex column and the active fractions were hydrolyzed with acid to give the same chrysophanol, diterpenone and d-glucose. After oral administration of these components, nitrosodiphenylamine condensates and chrysophanone could be detected from the large intestine, but the diarrhea activity of mice treated with chloramphenicol to inhibit the proliferation of intestinal bacteria was halved. Ketone production also decreased.
9. The impact on the secretion of gastric juice Consumption of cassia on an empty stomach can promote the secretion of gastric juice.
10. Inhibition of the action of 15-hydroxyprostaglandin dehydrogenase (15-OH PGDH) The diuretic prostaglandin E2 is converted to 15-keto prostaglandin via the action of 15-hydroxyprostaglandin dehydrogenase and is eliminated in vitro and inhibited. This in vivo reaction can prolong the diuretic effect. Cassia water extract inhibits 15-OH PGDH activity. After being extracted sequentially with ethane, chloroform, methanol, and water, the enzyme activity inhibitory substance was isolated by column analysis, and the IC50 of the indole derivatives meglumine and meclizine was 1.064×10 mol/l, 1.666×10 mol/L, respectively. The IC50 values ​​of the coexisting indole derivatives chrysophanol and rhubarb methyl ether were 1.789×10 mol/L and 1.236×10 mol/L, respectively, and the inhibitory activities were all weak.
11. Toxicity experiments demonstrated that cariogenic compounds in medicinal plants are carcinogenic. Most of the hydroxy aglycones are mutagenic to Salmonella typhimurium TA-1537. Tests on mammalian cells have shown that there is a significant structure-activity relationship for the reproductive toxicity of hydroxy steroids, when the 1, 3 hydroxyl (such as emodin) and the side chain of hydroxymethyl (such as 2-hydroxy fluorene ketone, aloe vera In the case of emodin, these quinone compounds have reproductive toxicity. However, the toxicity of Cassia itself remains to be studied. [1]
12 treatment of acute conjunctivitis: cassia seed, chrysanthemum, Poria, green medlar each 15g. Shuijianbi.
13. Treatment of acute keratitis: cassia seed 15g chrysanthemum 9g ginseng herb 9g schizonepeta 9g berberine 6g wormwood 12g. Shuijianbi.
14. Treatment of habitual constipation: Cassia 18g Yu Liren 18g. Boiling water brewing tea.
15. Treatment of night blindness: Cassia, wolfberry fruit 9g pig liver right amount. Water to cook liver soup.
16. Treatment of bird head: Cassia two or two of the skin. On the drug Yao Xia Luo for every time after the food to adjust a money to drink a porridge.
side effect
Cassia has its adverse reactions as a blind Chinese herb, and it also has its unsuitable population. Different proportions of cassia seed are added to foods that are completely nutritious, and the body weight of rats is decreased as the proportion of the drug increases. Clinical use of this product is oral hypolipidemic, after taking medicine. In 9% of cases, abdominal bloating, diarrhea, and nausea were initially present, but they disappeared on their own without affecting the continued medication.
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