Release date: 2016-08-08
Standard molecular assays for analyzing DNA are expensive and time consuming. However, the biochip test produced by Randox Laboratories can be tested multiple times in a single blood sample, saving time and cost, and facilitating rapid diagnosis.
The apolipoprotein E ( APOE ) gene plays a key role in lipid metabolism and is recognized as the most important genetic risk factor for Alzheimer's disease and other neurodegenerative diseases.
The APOE gene has three subtypes: e2 , e3, and e4 . The e4 subtype increases the risk of late-onset Alzheimer's disease, which may also be associated with early memory loss.
Alzheimer's disease (Alzheimer's disease) is a form of dementia that causes memory, thinking and behavioral problems. Symptoms develop slowly and worsen over time until they are severe enough to interfere with daily work.
The offspring inherit an APOE gene from each of the parents . If a person inherits a variant APOE gene from a father or mother , their chances of developing Alzheimer's disease triple. The probability of developing this disease in children who inherit two variant APOE genes from both parents increased by 8-12 times.
About 25% of people inherit an APOE e4 replication gene. If you inherit two, the risk of illness increases by a factor of 10 or more.
Biochip blood testing can accurately measure the status of APOE4 through a person's plasma sample – combined with medical history, family history, drug use, and lifestyle – to help provide patients with relevant information, counseling, and personalized medical care. .
“This is the first time we have used this chip technology to test the risk of Alzheimer's disease,†said Dr. Emma C. Harte , a research scientist at the Randox Laboratory . “This type of testing is very important. We need to understand and diagnose Alzheimer's disease and let patients understand the risks, consider medications, and even change their lifestyles as soon as possible.â€
Biochip and standard molecular diagnostic test results are identical
The results of the research published at the 68th Annual AACC Scientific Conference and Clinical Laboratory Expo in Philadelphia were analyzed and compared by 384 samples of biochip blood test and standard molecular diagnostic test. Sex.
The Randox Laboratory teamed up with colleagues from the University of Vienna Medical School in Austria. After comparing the two test results, they found that the biochip test results were 100% correct.
Biochip testing allows clinicians and researchers to get results within 3 hours, which allows doctors to quickly assess a person's risk of developing Alzheimer's disease.
Source: Noble
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