Intestinal microbes affect the immune cell activity in the brain of mice with multiple sclerosis

Posted on

According to a study published online this week in Nature, Microglial control of astrocytes in response to microbial metabolites, changes in the gut microbiota altered the activity of immune cells in the brain of experimental multiple sclerosis (MS) mice. This study expands our understanding of the interaction between the gut and the brain, or helps develop new therapies for multiple sclerosis and other neurological diseases.
Long-range regulation of immune cells in the brain.
Hartmut Wekerle
In multiple sclerosis, the brain's usually silent immune system is awakened, and non-neuronal cells (microglia and astrocytes) are activated. Francisco Quintana and colleagues at Harvard Medical School in the United States showed how the metabolite of dietary tryptophan produced by intestinal bacteria inhibits the pro-inflammatory activity of these two types of cells in a mouse model of multiple sclerosis. Further research on brain tissue in multiple sclerosis suggests that similar mechanisms exist in the human brain.
The aromatic hydrocarbon receptor limits the pro-inflammatory transcriptional response of microglia during encephalomyelitis.
Rothhammer et al.
When the metabolite of dietary tryptophan binds to a specific receptor on the cell surface, the activity of these immune cells changes. The same receptor will also bind to other naturally occurring compounds, including derivatives from plants such as broccoli. Perhaps one day, therapies targeting related molecular pathway components have been shown to be helpful in the treatment of multiple sclerosis, but the study also suggests that inflammatory brain diseases can be inhibited through the gut or indirectly.

Foot Spa Machine With Heat

A Foot Spa Machine with heat is a device used to provide a relaxing and therapeutic foot massage. It usually has a basin filled with warm water and has various massage settings such as vibration, bubbles, and rollers. The heat function helps soothe tired and aching feet, while the massage setting provides a deep-tissue massage that helps improve circulation, reduce tension, and relieve pain. Some foot spas also come with removable attachments, such as pumice stones and brushes, for extra exfoliation and cleansing. Overall, a foot spa machine with heat is a great tool for anyone looking to pamper their feet and promote overall relaxation and wellness.

Foot Spa Machine With Heat,Bubble Foot Bath Massager,Foot Massage Machine,Pedicure Foot Spa Machine

Huaian Mimir Electric Appliance Co., LTD , https://www.mmfootspa.com