A medical research paper recently published online by Nature magazine in the United Kingdom states that a body temperature preservation method called "life support system" may help improve the transplant effect and increase the number of available donor livers, thereby reducing waiting for liver transplantation. The mortality rate.
Liver transplantation is a surgical treatment that restores liver function in patients with end-stage liver disease. However, with the increase in the incidence of liver disease, the supply of liver for transplantation is in short supply. Many potential donors are considered too risky because they are very vulnerable to damage during cryopreservation. Liver viability cannot be measured during cryopreservation because normal cellular activity is suppressed during this period.
The medical community believes that a potential solution is to maintain the donor liver at body temperature, that is, to provide the donor liver with oxygenated blood, drugs, and nutrients through normal temperature mechanical perfusion (NMP), just as it is to provide a patient with a life support system. The liver can be preserved for 24 hours by this method, and in the future this method will also support the monitoring of liver viability during treatment and repair if necessary.
This time, David Nasrall, a scientist from the University of Oxford in the United Kingdom, and his colleagues conducted the first randomized trial of 220 liver transplant patients and compared traditional frozen storage methods and room temperature mechanical perfusion methods. Based on the measurement results of the biomarkers of liver injury, the team found that the normal temperature mechanical perfusion method had 50% less damage to the donor liver than the cryopreservation method, an average liver preservation period of 54%, and an organ abandonment rate of 50%. In addition, the researchers found that after one year of transplantation, there was no significant difference in the incidence of biliary complications, graft liver survival, and patient survival.
Scientists from the University of Innsbruck Medical School in Austria wrote in an accompanying news and opinion article that this method of organ preservation under conditions close to normal conditions not only helps to enhance liver transplantation, but also helps to improve liver surgery and organs. Nursing. (Reporter Zhang Mengran)
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