Han Chunyu is in the laboratory. Recently, 20 Chinese and foreign scholars published papers questioning that Han Chunyu's experiment could not be repeated. Profile picture
Recently, an academic paper entitled "Questions about NgAgo" co-authored by 20 scholars at home and abroad was published in the journal Protein & Cell. This is also the first public publication, specifically for academic papers that cannot repeat the Han Chunyu NgAgo experiment. Han Chunyu responded that the scientific paper will respond with scientific papers and will publish the recent experiments. But he said that the experimental papers will not be published immediately.
The paper said that Han Chunyu experiment can not be repeated
Since Han Chunyu’s article has been published for more than six months, there is still no laboratory publicly declared that the experiment has been repeated successfully. Yesterday, the reporter learned that an academic paper entitled "Questions about NgAgo" was published online in the journal Protein and Cell.
Han Chunyu
According to the magazine's official website, it was co-founded by China's Higher Education Press, Beijing Institute of Bioscience and the Chinese Biophysical Society.
This paper was jointly published by 20 scientists at home and abroad, and it was questioned that Han Chunyu's experiment could not be repeated. The authors include 13 Chinese scholars who have previously been unable to repeat Han Chunyu, and 7 new scholars, such as Shawn Burgess, professor of the NIH Human Genome Research Institute, Cheng Linyi, professor of Johns Hopkins University, and School of Life Sciences, Sun Yat-Sen University. Associate Professor Huang Jun is waiting for scholars.
Solve academic problems through academic channels
One of the authors, Huang Zhiwei, a professor at the School of Life Science and Technology of Harbin Institute of Technology, told reporters that the content of the paper is mainly due to the fact that their respective laboratories cannot reproduce the experimental results of Han Chunyu NgAgo. In addition to the previous 13 scholars, the author also has new scholars. “Everyone communicated in the same group, all of them repeated experiments, but did not get the expected results.â€
Another paper author, Wenzhou Medical University professor Gu Feng explained that this is a scientific paper published in the form of a letter, which is a verification of Han Chunyu's thesis.
Published in the form of a paper, Huang Zhiwei seems to solve academic problems through academic channels. "Academic proof is still to publish academic results," he said. "The results of everyone are sent out. I hope that more scholars can understand the real experimental situation of this technology. If others repeat it but do not repeat it, they are not isolated".
Focus 1
What are the 20 scholar papers questioning?
According to the paper, the experiments were independently performed by different laboratory researchers, but none of the experimental results demonstrated that NgAgo has any genome editing activity. Huang Zhiwei told reporters that his laboratory has been repeated many times, but he has not found the effect of "cutting" and did not get the expected results.
In addition, the paper also needs "excellent experimental skills" for the re-emergence of the results of Han Chunyu's previously stated papers, as well as repeated experiments, which may be questioned because of the activity of NgAgo on the mycoplasma or bacteria in culture.
The paper writes that neither the initial release nor the information that was later updated on the global scientist's plasmid-sharing non-profit organization Addgene's website does not seem to involve any steps that seem to require "excellent experimental skills." At the same time, it is not possible that all cells in an independent laboratory are contaminated, resulting in consistent negative results.
At the end of the paper, scholars mentioned that it is hoped that Han Chunyu will clarify the uncertainty of NgAgo and provide the details needed to repeat the experimental results.
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