As a direct performer of life activities, proteins participate in almost all processes of life, such as genetics, development, reproduction, metabolism of matter and energy, stress, and so on. Revealing the specific functional mechanisms of thousands of proteins in living organisms is the core of protein research and one of the most challenging areas of life science research in the post-genome era.
Protein research is essential throughout all areas of scientific research and there is a huge research space. Take the diagnosis and biotherapy of translational medicine as an example:
In the field of diagnosis, the detection of various levels of cancer can be predicted earlier by detecting the levels of AFP, CEA, GP73, and HE4 in serum. Currently, there are only dozens of protein indicators that have been commercialized for diagnosis, and proteins that have been studied and defined. The number of more than 17,000 is just the tip of the iceberg. With the rapid development of proteomics technology, research on body fluid samples from a large number of patients and normal people, especially for patients with body fluid samples of different age groups, different diseases and different disease courses, will produce more and more valuable diagnosis. Detection of protein markers, the discovery of these indicators greatly improved the early detection rate of tumors.
In the field of biological therapy, humanized antibodies based on PD-1 and PD-L1 and leukemia CarT cell therapy based on CD19, CD20, CD138, etc., all target cells on the cell surface. The research community is also investing a large amount of money in the study of surface protein changes in tumor cells and immune cells during tumorigenesis and progression, in order to find specific treatments for protein targets.
The above-mentioned targets for diagnosis and treatment are actually more of a "fruit". What causes the cause, and the reasons for their formation are of greater value to our prevention of disease and treatment of diseases, which requires us. The entire signaling pathway of the protein was studied.
At present, we have a lot of methods and tools for protein research, and more and more people are joining the ranks of protein research. However, the incompleteness of equipment, the difficulty of obtaining samples, and the complexity of operation have become obstacles in the research of protein. Jin Kairui pays attention to the whole research idea of ​​protein, and establishes six service platforms for proteome, detection and analysis, virus packaging, gene service, protein expression and antibody preparation, providing protein screening and identification, protein upstream research, target protein preparation and interaction protein discovery. A series of protein research technology services, dedicated to providing the most professional and best service for the majority of protein researchers.
“Reading†refers to the identification or quantitative detection of unknown single proteins or complex proteins in biological samples. We mainly use various biological techniques developed based on mass spectrometers.
"Solution" - refers to the confirmation and in-depth interpretation of predicted protein information, which may require some intervention to increase or decrease the expression of endogenous proteins, such as interference, knockout or overexpression, or Simulation studies were performed in vitro using other means.
"Write" - refers to the preparation by in vitro recombination, and through a series of experiments to confirm its structure and function as close to the natural state as possible, in order to carry out subsequent research as a tool.
“Use†means a product or platform that cooperates with customers to develop the results of protein detection and synthesis into market demand standards, to jointly break down barriers to research and application, and to help customers to bring their research results to market and let their research results Maximize the value of the application to realize the value of the protein field in the life sciences.
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