Release date: 2017-03-31
What if we can "stick" the fluorescent material on the surface of cancer cells? Surgeons can see at a glance where cancer cells are. This is a new study by Michigan University of Technology researchers: fluorescent probes.
The researchers said: "It is difficult for doctors to find cancer tissue." During the surgery, the cancer antibodies produced in the test tubes are mixed with the enzymes used to highlight the malignant tumors. Although they can bind cancer cells, they have a disadvantage.
"They are colorless, and it's hard to see them. It's a problem." The research team has now developed a detector that captures antibodies that mix enzymes and causes them to glow under fluorescent light.
Fluorescent probes have some appealing medical attributes:
Near-infrared fluorescence, which can penetrate deep tissues and help doctors detect malignant tumors buried deep in healthy tissues;
Reduce the "noisy background" during surgery because other tissues usually emit blue or green light;
Non-toxic at low concentrations;
Rapid response to enzymes at ultra-low concentrations;
The fluorescence is stable and long lasting and can last up to several hours during surgery.
The detector-bound enzyme is called beta-galactosidase, which is used to broadly label a variety of antibodies for use in multiple medical procedures, including cancer surgery. "If we can make beta-galactosidase glow during surgery, the surgical outcome will go a long way."
In the paper, the researchers showed how the probe binds to β-galactosidase. In the future, they are willing to work with the medical team to further improve their systems, using enzyme-labeled cancer antibodies as a surgical guide.
Source: Noble
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