Microscopic expansion techniques understand RNA empire at the nanoscale

MIT engineers have developed an RNA molecular visualization program that helps researchers understand RNA molecules in intact tissues with higher resolution and even pinpoint the location of RNA in cells.

The key step in this new technology is to expand the organization before imaging. By expanding the size of the tissue itself, you can find RNA using a common high-resolution imaging microscope.

“Now we can understand the spatial precision of RNA by relying on the expansion process of cells, and even we can easily find RNA in large intact tissues,” said Ed Boyden, associate professor of bioengineering at the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology. The research-related article was published in the 2016 issue of Nature Methods.

Studying the distribution of RNA in cells can help scientists understand the mechanisms by which cells control gene expression. It can also help experts investigate the causes of some RNA-induced diseases and find viable treatment options.

Boyden and his colleagues first described this underlying technology, the microscope (ExM) expansion technology, which they have successfully applied last year to describe proteinaceous material in large samples of brain tissue. The technology-related article was published in an article in the July 4 issue of Nature Biotechnology, and research shows that the MIT research team has now proposed a new version of the technical solution. The use of existing chemicals is more convenient for researchers to use.

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