How to eat is not fat! New pills may help people suppress obesity
August 24, 2018 Source: World Wide Web
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];[Global Network Comprehensive Report] According to a foreign media report on August 22, a study shows that scientists have developed the world's first anti-obesity drug, which can inhibit the growth of fat-producing cells. This drug prevents the body's fat production process and helps resolve heart disease, cancer and dementia.
This pill called PO53 causes fat such as cholesterol to be consumed by the muscles without accumulating in the body. In a study of mice, animals taking this drug remained slim even when eating high-fat foods. Experts hope that it will also play a role in the human body. By 2045, nearly a quarter of obese people around the world are expected, and researchers say their findings are a "significant improvement" in response to this crisis.
Scientists at the University of New South Wales in Sydney, Australia, initially experimented with finding a way to prevent type 2 diabetes. This condition is caused by obesity, but it is caused by resistance to the blood sugar control hormone insulin. However, scientists later discovered that the drug did not affect blood sugar, but prevented the body's body fat. The researchers say their findings are the first time scientists have successfully stopped obesity.
Reducing obesity can reduce cancer and heart disease deaths. Now, they say the drug may have a greater impact and reduce obesity rates, thereby reducing the risk of diseases such as type 2 diabetes, cancer, heart disease and dementia that may affect obese people.
Professor Nigel Turner, one of the authors of the study, said: "Because obesity is a serious risk factor for many different diseases, including cardiovascular disease and cancer, any new treatment can bring a wide range of benefits in the fight against obesity. ."
This drug works by blocking an enzyme called ceramide synthase 1 (CerS1). The drug causes the body to burn fat instead of storing fat. When this enzyme is blocked by PO53, the body burns fat in the muscles, such as cholesterol and triglycerides from food, rather than storing it in fat tissue. In the past, strong, suitable drugs used to control fat production have been difficult to produce. However, PO53 prevents the activity of the lipogenic enzyme CerS1, reducing the body's fat without affecting insulin resistance in high-fat diet mice.
Professor Turner and his colleagues believe that this is because the drug promotes the burning of fatty acids in the muscles of animals. One of the authors of the study, Professor Anthony Don of the University of Sydney added: "From here, I want to develop a drug for CerS1 and other enzymes to see if it produces a stronger anti-obesity and insulin-sensitive response. "Although these drugs need to do more work before they are put into clinical use, so far, our work is a very important step in this direction." (Ding Chunhui Li Zongze)
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