New treatment strategies for functional recovery after spinal cord injury
July 24, 2018 Source: Science and Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];There are a lot of nerves hidden in the spinal cord. Once the injury, it may lead to functional loss such as sputum. How to restore the limb function of the patient becomes a difficult problem to be solved. The reporter recently learned from Nantong University that the academic team of Dr. Gu Xiaosong and the research team of He Zhigang of Harvard University published a result in the journal Cell, which proved for the first time that the disorder of excitability of interneurons is hindering functionality after spinal nerve injury. An important mechanism for recovery, while exploring a new therapeutic strategy that can effectively improve functional recovery by balancing the excitability of inhibitory neurons in the spinal cord.
There are more than 300,000 to 500,000 patients with spinal cord injury each year, and more than 5 million people with spinal cord injury in China. More than 90% of patients with spinal cord injury clinically still have some residual nerve fibers attached to both ends of the injured spinal cord, but more than half of the patients are completely lost in function. This is a major medical problem that has not yet been solved in the world. The underlying cause is that the mechanism that hinders functional recovery after spinal cord injury is unclear.
Researchers have directly researched and screened small molecule drugs as a breakthrough to study and establish a complete and globally leading research system and method for central nervous system damage repair. Studies have shown that by regulating cell membrane ion channel protein KCC2 can effectively antagonize the excitability of inhibitory neuronal cells, improve the excitability and imbalance of interneurons caused by spinal cord injury, and strengthen the transmission of "brain-spinal" nerve bypass signals , thus effectively enhancing the recovery of motor function. (Reporter Zhang Wei)
Levamisole As Immunomodulator,Levamisole As Chemo,Levamisole Vs Albendazole
Shaanxi YXchuang Biotechnology Co., Ltd , https://www.peptidenootropics.com