The use of stem cells to make mouse and human embryo models in the laboratory is rapidly moving forward, while at the same time bringing profound legal and ethical issues. In view of this, the British "Nature" magazine recently published a review article, calling on the international community to discuss and point the way for this fast-developing research field.
In the comments, scientists including the Dutch Huber Institute and the Jackson Laboratory in the United States believe that the legal status of human stem cell-derived embryonic models and the application of such research must be discussed in an open and transparent manner to help countries develop The corresponding policies and regulations. They wrote: "Effective communication with the public is the key to ensuring a prudent approach to the prospects of research."
In the past 18 months, researchers have developed mouse models that contain yolk sac and placental tissue. The review article pointed out that it is not too far off to make human models similar to human stem cells. Such models are expected to improve contraceptives, improve the effectiveness and safety of in vitro fertilization (IVF), and promote the prevention and treatment of developmental disorders.
In the article, the scientists raised several questions that need to be discussed publicly, including whether the embryonic-like entities in the laboratory should be treated as human embryos now and in the future, and how the limits of culturing intact human embryos should be set. They urged funding agencies and the scientific and medical community to take the lead in discussions.
The existence of embryonic-like entities as human embryos has been a huge controversy. Some scholars believe that although human embryos have the potential to develop into complete human beings, there is still a difference between people with potential and facts. The opposing view is that human embryos should be regarded as having adult development from the beginning of fertilization. ability.
The published article belongs to the journal Nature, rather than the peer-reviewed Nature paper, an authoritative review of scientific research and its impact.
As early as the 1980s, there was already a discussion in the UK about whether a human embryo model should be allowed. From a medical point of view, in vitro research on human embryos will undoubtedly benefit humans, but from an ethical perspective, is the embryo equivalent to the person with the facts? Should it have the same moral status? The parties to the dispute could not reach an agreement. Therefore, the "14-day deadline" principle was born, that is, human embryos should not be cultured in vitro for more than 14 days. This important rule has continued to this day. Nowadays, there are continuous breakthroughs in embryo culture technology, calling for people to reconsider the existing framework, in order to find a best solution in line with scientific interests, social interests and potential medical benefits.
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