Yesterday, innovative biotechnology company ABIVAX announced that the chronic immunodeficiency virus (HIV, commonly known as HIV) infection of the company's leading new drug candidate ABX464 has shown a reduction in viral load in the body, which is through the peripheral blood list. Total HIV viral DNA in nuclear cells (PBMC) was measured.
Molecular structure of ABX464 (Source: ABIVAX official website)
ABX464 is the first (in-in-class) small molecule compound in the field of inhibition of HIV replication through a novel mechanism of action, which has the potential to reduce or eliminate the virus, which is expected to reduce the viral load of HIV-infected patients for a long time. . ABX464 is designed to target the integrated genetic material of immune cells after invasion by the HIV virus. Since the viral stocks in these immune cells are not affected by existing antiretroviral therapies, a rebound in viral load is caused once the treatment regimen is stopped. ABX464 inhibits the biosynthesis process of viral RNA required for HIV virus replication. Preclinical data obtained from this unique pharmacodynamic model show that ABX464 has the potential to reduce or eliminate the viral reserve of HIV virus; induce long-term viral load control; Prevent the emergence of drug-resistant HIV mutants; require shorter courses of treatment than standard treatment options; promise to reduce medical costs and provide a wider range of treatments.
Mechanism of action of ABX464 (Source: ABIVAX official website)
Active Pharmaceutical Ingredients
Active Pharmaceutical Ingredients(API) refer to the raw materials used in the production of various preparations. They are the effective ingredients in the preparations. They are various powders, crystals, extracts, etc., prepared by chemical synthesis, plant extraction or biotechnology, but Substances that the patient cannot take directly. API is intended to be used in any substance or mixture of substances in the manufacture of pharmaceuticals, and when used in pharmaceuticals, it becomes an active ingredient of the pharmaceuticals. Such substances have pharmacological activity or other direct effects in the diagnosis, treatment, symptom relief, treatment or prevention of diseases, or can affect the function or structure of the body. According to its source, active pharmaceutical ingredients are divided into two categories: synthetic chemical active Pharmaceutical ingredients and natural chemical active Pharmaceutical ingredients.
Chromium Picolinate,Tianeptine,6-Paradol,Aminobutyric acid,acetylcysteine,L-Carnosine
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