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Quick Details of Active Pharmaceutical Ingredients TrilostaneÂ
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Product Name:Â Trilostane
Synonyms: TRILOSTANE;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al;modrenal;
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CAS:Â 13647-35-3;
MF: C20H27NO3;
EINECS: 237-133-0;
MW: 329.43.
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Product name: | Trilostane |
Other Name: | TRILOSTANE;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al;modrenal; Â |
Original: | China |
CAS: | 13647-35-3 |
Molecular formula: | C20H27NO3 |
MW: | 329.43. |
EINECS: | 237-133-0 |
Brand name | NJBNSteroid |
Leading time | within 24 hours upon receipt of payment |
Delivery | Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS |
Purity | 99% |
Package | Discreet and Hidden package according to specific requirement |
Appearance | White Powder |
Certification | SGS, ISO 9001, KOSHER |
Payment Terms | Western Union, Money Gram , T/T, Bitcoin |
Minimum Order Quantity | 10g |
Price | Negotiable |
Usage | An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer |
Molecular structure | Â Â |
Overview of Active Pharmaceutical Ingredients Trilostane
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1. Trilostane is an inhibitor of 3beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome and primary hyperaldosteronism. These are both disorders where excess amounts of corticosteroid hormones are produced in the body.
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2. Corticosteroids are essential for the body to make use of carbohydrates, fats and proteins and for a normal response to stress. They are also necessary for the regulation of salt and water balance in the body. Trilostane helps prevent the production of corticosteroids, controlling the symptoms associated with these disorders.
3. Trilostane can also be useful in the treatment of breast cancer that has relapsed in women who have gone through menopause.
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Technical Test Sheet of Active Pharmaceutical Ingredients Trilostane
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Items | Specification | Results | |
Appearance | white oralmost white,crystalline powder | Conform | |
Solubility | Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride. | Conform | |
Identification |
A | The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64. |
Conform |
B | Infraed absorption spectrophotometry. | Conform | |
C | Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution. |
Conform |
|
D | An orange-red color develop in methylene chloride layer. | Conform | |
E | It geves reaction (a) of sulphates. | Conform | |
Appearance of solution |
Solution S is clear and not more intensely coloured than reference solution in BY6. | Conform | |
Optical rotation | negative 0.10° to +0.10°determined on solution S. | +0.01° | |
Acidity or alkalinity | NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red. | Conform | |
Related substances |
Impurity J ≤0.20% | Conform | |
Any other impurity ≤0.30% | Conform | ||
Total impurity ≤1.0% | Conform | ||
Boron | ≤50ppm | Conform | |
Sulphated ash | ≤0.10% | 0.06% | |
Loss on drying | ≤0.5% | 0.30% | |
Assay(on dried basis) | 98.0~101.0% | 99.5% | |
Conclusion | The test results above BP2009 |
Medical Application of Active Pharmaceutical Ingredients Trilostane
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1. Uses in dogs:
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Trilostane was withdrawn from the United States market in April 1994. However, it was approved in 2008 for the treatment of Cushing's disease (hyperandrenocorticism) in dogs.
It is also the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs.
(1). has kidney or liver disease.
(2). takes certain medications used to treat heart disease.
(3). pregnant.
(4). taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
(5). had an allergic reaction to this or any other medicine. Active Pharmaceutical Ingredients Trilostane CAS 13647-35-3 for Breast Cancer
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Quick Details of Active Pharmaceutical Ingredients TrilostaneÂ
Â
Product Name:Â Trilostane
Synonyms: TRILOSTANE;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al;modrenal;
Â
CAS:Â 13647-35-3;
MF: C20H27NO3;
EINECS: 237-133-0;
MW: 329.43.
Â
Product name: | Trilostane |
Other Name: | TRILOSTANE;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al;modrenal; Â |
Original: | China |
CAS: | 13647-35-3 |
Molecular formula: | C20H27NO3 |
MW: | 329.43. |
EINECS: | 237-133-0 |
Brand name | NJBNSteroid |
Leading time | within 24 hours upon receipt of payment |
Delivery | Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS |
Purity | 99% |
Package | Discreet and Hidden package according to specific requirement |
Appearance | White Powder |
Certification | SGS, ISO 9001, KOSHER |
Payment Terms | Western Union, Money Gram , T/T, Bitcoin |
Minimum Order Quantity | 10g |
Price | Negotiable |
Usage | An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer |
Molecular structure | Â Â |
Overview of Active Pharmaceutical Ingredients Trilostane
Â
1. Trilostane is an inhibitor of 3beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome and primary hyperaldosteronism. These are both disorders where excess amounts of corticosteroid hormones are produced in the body.
Â
2. Corticosteroids are essential for the body to make use of carbohydrates, fats and proteins and for a normal response to stress. They are also necessary for the regulation of salt and water balance in the body. Trilostane helps prevent the production of corticosteroids, controlling the symptoms associated with these disorders.
3. Trilostane can also be useful in the treatment of breast cancer that has relapsed in women who have gone through menopause.
Â
Technical Test Sheet of Active Pharmaceutical Ingredients Trilostane
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Items | Specification | Results | |
Appearance | white oralmost white,crystalline powder | Conform | |
Solubility | Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride. | Conform | |
Identification |
A | The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64. |
Conform |
B | Infraed absorption spectrophotometry. | Conform | |
C | Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution. |
Conform |
|
D | An orange-red color develop in methylene chloride layer. | Conform | |
E | It geves reaction (a) of sulphates. | Conform | |
Appearance of solution |
Solution S is clear and not more intensely coloured than reference solution in BY6. | Conform | |
Optical rotation | negative 0.10° to +0.10°determined on solution S. | +0.01° | |
Acidity or alkalinity | NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red. | Conform | |
Related substances |
Impurity J ≤0.20% | Conform | |
Any other impurity ≤0.30% | Conform | ||
Total impurity ≤1.0% | Conform | ||
Boron | ≤50ppm | Conform | |
Sulphated ash | ≤0.10% | 0.06% | |
Loss on drying | ≤0.5% | 0.30% | |
Assay(on dried basis) | 98.0~101.0% | 99.5% | |
Conclusion | The test results above BP2009 |
Medical Application of Active Pharmaceutical Ingredients Trilostane
Â
1. Uses in dogs:
Â
Trilostane was withdrawn from the United States market in April 1994. However, it was approved in 2008 for the treatment of Cushing's disease (hyperandrenocorticism) in dogs.
It is also the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs.
(1). has kidney or liver disease.
(2). takes certain medications used to treat heart disease.
(3). pregnant.
(4). taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
(5). had an allergic reaction to this or any other medicine.
Vitamins are a type of trace organic substances that humans and animals must obtain from food in order to maintain normal physiological functions. In terms of physiological functions, vitamins are neither a raw material for tissues nor a substance for supplying energy, but they are an indispensable substance for the body. It has many types and different chemical structures. Most of them are the components of the coenzyme (or prosthetic group) of certain enzymes. They are the indispensable compounds for maintaining the normal growth (growth, health, reproduction and production function) of the body. It plays a catalytic role in the body to promote the synthesis and degradation of major nutrients (proteins, fats, carbohydrates, etc.), thereby controlling metabolism. Vitamins are essentially low-molecular organic compounds. They cannot be synthesized in the body, or the amount synthesized is difficult to meet the needs of the body, so they must be supplied from the outside. The daily requirement of vitamins is very small (usually measured in milligrams or micrograms). They are neither a raw material for body tissues nor a substance for energy supply in the body. However, they do not regulate material metabolism, promote growth and development, and maintain physiological functions.
Vitamin K2 MK-7, Vitamin C, Vitamin E, Vitamin K2, Vitamin H, Vitamin D3
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