Low dose vitamin C can "get better" cancer cells
July 12, 2018 Source: Science and Technology Daily Author: Li Daqing
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Vitamin C can fight cancer. Since the 1970 Nobel Prize winner and biochemist Pauling put forward this view, the controversy has continued. Because high dose of vitamin C can be used in tumor treatment, its instability and high dose toxicity make the development and utilization of vitamin C in tumor treatment stagnant.
Recently, the Ciweimin Research Group of the Beijing Institute of Genomics of the Chinese Academy of Sciences and the Zhou Liqun Research Group of the First Hospital of Peking University cooperated with low-dose vitamin C and its derivative magnesium phosphate to the renal cancer cell line in the normal human C level. It was found to effectively increase the level of 5-hydroxymethylcytosine (5hmC) in cells and inhibit the growth and migration of tumor cells to some extent. The relevant research results are published online in the latest issue of the European Molecular Biology Organization Report.
The mechanism by which vitamin C inhibits tumor cell growth is that vitamin C reprograms cancer cells by up-regulating the level of 5hmC in transparent renal cell carcinoma, thereby reducing the degree of tumor malignancy and almost no specific damage to normal cells.
The results of this experiment were also confirmed in the cells of nude mice xenografts and primary clear renal cell carcinoma patients. The increase in 5hmC levels is accompanied by a decrease in the malignancy of tumor cells. In other words, the 5hmC reprogramming mode makes kidney cancer cells more prone to normal cells.
For the first time in this study, it was confirmed that vitamin C can increase the level of 5hmC by promoting the activity of a dioxygenase, reprogramming 5hmC to a "normal" state, thereby reversing the tissue structure and cell morphology of renal cancer cells, and exerting resistance. Tumor effect. Experts pointed out that this discovery not only provides new ideas for the treatment of kidney cancer, but also provides the latest basis for the important role of epigenetics in cancer treatment.
According to reports, the research results have been applied for patents. At the same time, the prospective study of vitamin C combined with targeted drugs for the treatment of transparent renal cell carcinoma has also been carried out in cooperation units.
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