Key regulatory proteins can cultivate human anti-enemy "new recruits"
July 18, 2018 Source: Science and Technology Daily Author: Zhang Ye
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];How will the "combat forces" inside the human body respond when our body itself suffers from a viral and bacterial "enemy" invasion? Controlling antibodies to produce key human B cells is an important reserve for foreign enemies. Recently, the team of Wang Xiaoming of Nanjing Medical University found that Uhrf1 protein is an indispensable factor influencing the qualification of “new recruitsâ€.
When the human immune system receives the "invasion" signal, it will first count a "combat force" in the human body - the antibody will be counted. If the power is insufficient to fight the virus, a new round of "recruitment order" will be issued. Antigens in the body are activated to recruit antibodies that are strong enough. After receiving the command, the human B cells that control the antibody enter the “new boot camp†(Growth Center GC). After training and selection, qualified soldiers can go to the charge.
How can I become a qualified soldier? Chen Chao, a member of the research team, told reporters that B cells have high affinity. As the affinity increases, the ability and speed of the antibody to clear the pathogen will be greatly improved.
Uhrf1 protein is the key to affecting B cells to stand out in the boot camp and get a certificate quickly. This quality is not enough (the absence of Uhrf1) directly leads to the growth of the strength of soldiers in the boot camp, but also affects whether it can quickly become a qualified soldier. The research team also found that the impact of this quality on the growth of soldiers was mainly caused by the first period of the growth of recruits, that is, the critical period when recruits faced elimination. The strength of growth is not enough, and the number of recruits entering the second round of selection will be greatly reduced.
The research results mean that in the future development of vaccines, we should always pay attention to and consider the role of Uhrf1 protein, so that we can quickly and effectively train a combat force with strong combat capability, precise technology and psychological quality, and more effectively Protect human health. Related results (the apparent regulator Uhrf1 protein is resistant to viral infection by regulating germinal center B cell expansion and affinity maturation) has been published in the latest issue of the Journal of Experimental Medicine. (Reporter Zhang Wei)
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