Release date: 2018-06-13
Photodynamic therapy belongs to the field of photomedicine. It is a new technology that combines the use of photosensitizers and corresponding light sources to selectively destroy diseased tissues through photodynamic reactions. Its anti-tumor effect is mainly to use laser irradiation of a specific wavelength, so that the excited photosensitizer transmits energy to the oxygen in the surrounding tissue, and generates active substances such as singlet oxygen to produce cytotoxicity, resulting in damage or death of surrounding tumor cells. . In recent years, with the deployment of precision medical strategies in various countries, the development of photosensitizers with specific functions for tumor cells has become a hot spot, and has attracted much attention at home and abroad.
Under the support of the National Natural Science Foundation of China, the Natural Science Foundation of Fujian Province, the Hundred People Program of Fujian Province, and the Special Project of the Chinese Academy of Sciences, Chen Zhuo, the State Key Laboratory of Structural Chemistry of the Institute of Research on Physical Structures of the Chinese Academy of Sciences, is building new materials. At the same time of structural design and biological application platform, the research and development of a series of new photosensitizers and their photodynamic therapy research were carried out. The research group successfully prepared high-purity and single-component monocarboxy-substituted zinc phthalocyanine by solid phase synthesis method, which broke through the key technical problems of traditional phthalocyanine photosensitizer components, uncertain components and insufficient tumor targeting. On this basis, a series of new phthalocyanine photosensitizers with more targeted functions for specific tumor cells have been developed to improve their targeting to tumor cells and to obtain more specific anti-tumor effects. At present, the research team and the Li Jinyu research group of the National and Local Joint Engineering Research Center of Biopharmaceutical and Photodynamic Therapeutic Technology of Fuzhou University School of Chemistry have reported an anti-tumor effect of self-assembled photosensitizers with intelligent targeting of tumor sites. The relevant results were published in ACS applied Materials & Interfaces 2018, 10, 15369-15380. The first author of the article is Jia Yuhua, a master student of Chen Zhuo's group. The research results provide a new idea for the development of efficient, highly targeted photosensitizers for precise tumor therapy in the future photodynamic therapy market.
Source: Fujian Institute of Material Structure
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