Ever since the deputy director of the House of Directors has been arrogant to the people, I have been pondering that such a young and ambitious hero is corrupt. My political consciousness is definitely not understanding this complicated process, but it reminds me of the tumor problem. Cancerous cells have long been considered the culprit of tumors, but a survey has found that the basic problem of tumor cells building tumor microenvironment (TME) or TME spawning tumors has not yet been determined.
If you are a cell in the young age, it is the healthiest cell, but it is cancerous when you are in the wind. It is thought-provoking. There are several arguments about the origin of the tumor. The most mainstream is the somatic cell variability theory (SMT), which believes that a certain amount of variation in cells accumulates cancer. However, there is no experimental evidence that a mutant cell will induce tumor after entering healthy tissue. Although experiments have shown that whole gene knockout can induce tumors, this time the entire tissue has been composed of variant cells and SMT cannot be proved. Another theory is the so-called Organizational Structure Field Theory (TOFT), which considers that the organizational environment is mutated first, while genetic variation and tumors are only the result of this change.
The organizational structure field is similar to the TME that is often said now. The tumor is not a bunch of independent serial killers, but a tightly organized underworld. The division of cells and signaling factors of various functions in TME is complex (including inhibition of immune response), forming a new body organization. This river and lake is not always intriguing, killing each other, and winning the winner. Sometimes they are embarrassed, arrogant, and use each other. Experiments have shown that only two tumor cells of different nature can exist together at the same time, otherwise they will be broken by each. Of course, there are also cells and signaling molecules responsible for communicating with normal tissue substances and energy to avoid being attacked by the immune system.
The human body begins with a fertilized egg and needs to face various environmental stresses such as tissue damage during its survival, so normal tissues require complex biological processes to form and maintain, and errors in these processes may form TME. Studies in the 1970s showed that some tumors can only occur when the tissue is damaged. Now a large amount of data indicates that the tumor must be adequately prepared for other healthy tissues, including immunosuppression. Most of the tumor cells leaving the primary tissue cannot be in other tissues. survive. The high functional and genetic heterogeneity of cancer cells within tumor tissues also suggests that environmental errors may have caused normal cells to emerge in different ways. So TME is at least as important as mutant cells.
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