Chinese herbal medicine "Glycyrrhiza" genome sequencing completed
November 01, 2016 Source: Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)]; A research group consisting of the Japanese Institute of Physical Chemistry, Chiba University, Kochi University, and Osaka University announced that they have performed genome-wide sequencing of the Chinese herbal medicine "Glycyrrhiza" and successfully obtained 94.5% of the genetic information of all the putative genes.
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Licorice is a leguminous plant widely used in various Chinese medicines and is an important raw material for traditional Chinese medicine. It has many functions such as improving liver function, treating peptic ulcer, anti-inflammatory and relieving pain and relieving cough. Glycyrrhizin, the main ingredient rich in licorice roots, is 150 times sweeter than granulated sugar and can be used as a non-glycosyl sweetener to prevent metabolic syndrome. At the same time, licorice is also an important raw material for medicine, cosmetics and natural sweeteners, and the demand is enormous. Genome sequencing can not only efficiently breed based on its genomic information, but also conduct in-depth research on the effective medicinal component glycyrrhizin genetics in order to achieve biosynthesis.
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The team selected the best quality "Ural Glycyrrhiza" in licorice for genome-wide sequencing. By analyzing the obtained genetic information, 34,445 protein genetic code codes were found. The research team used the genomic information of licorice to analyze and compare the genome information of other legumes with the whole genome. It was found that one of the pharmacological components and a part of the biosynthesis-related gene group of isoflavones formed a gene cluster. The research team further analyzed the biosynthesis-related gene family containing enzyme genes and found its genetic structure and genetic expression.
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At present, 90% of doctors in Japan use traditional Chinese medicine to treat diseases, and the amount of use increases year by year. Nowadays, 85% of Chinese herbal medicines such as licorice are imported from China. In order to meet the ever-expanding market demand, this research is important for molecular breeding and cultivation of Japanese licorice, improving the efficacy of Chinese herbal medicines, and in-depth study of useful genetic genes necessary for the production of medicinal ingredients. significance. (
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