PNAS: Scientists discover new fungal viruses
August 03, 2015 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];This virus infects Aspergillus fumigatus fungi, which can cause aspergillosis in humans. This fungus is targeted to infect lung organs and is a major cause of morbidity and mortality in individuals with low immunity.
This fungal virus, called Aspergillus fumigatus-1 (AfuTmV-1), consists of four double-stranded ribonucleic acids (dsRNAs) and a genome of genes with unique sequence characteristics. Unlike almost all viruses, its genetic information is not encapsulated in a shell but encapsulated in a virus-encoded protein. These ribonucleoprotein structures are first revealed by atomic force microscopy.
Most importantly, in the absence of a protein capsid, the AfuTmV-1 genome can itself infect fungi, a feature previously seen in dsRNA, including viruses. Therefore, the genome may be altered by direct introduction into the fungus by genetic engineering.
It is hoped that AfuTmV-1 will be used to develop a silencing vector, which is a tool that can cut off fungal genes, which can help to analyze what substances in Aspergillus fumigatus cause human aspergillosis.
AfuTmV-1 is a prototype of a novel family of fungal viruses, but it is not unique, as similar fungal viruses have also been found in different fungal genus, indicating the use of these dsRNA elements in the future fungal community to construct universal silencing vectors. Has the potential utility.
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