Japanese research unveils the mystery of c virus causing rapid death of chicken

A research team in Japan recently announced that they have discovered some of the mechanisms by which chickens die rapidly after infection with the highly pathogenic avian influenza virus (H5N1 virus), a result that has helped develop new therapies for a variety of infectious diseases.

Release date: 2014-12-23

A research team in Japan recently announced that they have discovered some of the mechanisms by which chickens die rapidly after infection with the highly pathogenic avian influenza virus (H5N1 virus), a result that has helped develop new therapies for a variety of infectious diseases.

The research team led by Professor Kyoto Hiroshi of Kyoto Prefecture University conducted the study. According to reports, in the highly pathogenic avian influenza virus, the H5N1 virus is very toxic and can infect humans. In general, after the chicken is infected with the virus, it does not gradually weaken like other diseases, but quickly dies.

When the research team used chickens to test the infection of the H5N1 virus in Indonesia, it found that the blood vessels of all organs of the chickens showed symptoms of bleeding and congestion. Their analysis of chicken lungs showed that the amount of endothelin in the vasopressor was about three times the usual level, while the amount of endothelin receptor was about 1.5 times the usual level.

The team believes that abnormal amounts of endothelin can cause sharp bleeding and ischemia, leading to rapid death of the chicken. When the chicken was injected with an inhibitor that blocked the action of endothelin and the receptor, the mortality rate on the fifth day after infection decreased from 100% to about 20%. However, the mechanism by which endothelins and receptors increase after infection with the virus is not known.

The team believes that bleeding disorders such as Ebola hemorrhagic fever should have the same mechanism. Sakamoto said: "In the treatment of human Ebola hemorrhagic fever, perhaps inhibitors of endothelin and receptors can act as therapeutic drugs."

Source: Xinhua News Agency

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